Section Gene Symbol Age Orientation Objective Veracity Veracity Support 10 paired-like homeodomain transcription factor 2 Pitx2 adult Sagittal 10X Confirmed Multiple Lines Match Matches In Situ Data Supported by Literature

BX BAC Address marker BX2019 RP24-215O15 EGFP

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Add this image to your album Download this image at the scale shown below. Founder Line: JS66 See all MMRRC strains for : Pitx2 Get this mouse from MMRRC: STOCK Tg(Pitx2-EGFP)JS66Gsat/Mmucd: Details, Order Get this BAC Clone from CHORI: BX2019 UCSC Genome Browser for this BAC Address: RP24-215O15

View other image sets for Pitx2

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Comment on this Gene: Two BAC lines are identical at P7. The E15-5 BAC data agrees with the in situ data from both BGEM and Genepaint.org. In the developing tectum, the BAC data shows less expression in the differentiated cells, compared with the in situ data. During the postnatal development, the BAC is correctly expressed in supra mammillary nucleus, zona incerta, subthalamic nuclei. However, there is hardly any expression in the medial mammillary nucleus. The lateral hypothalamus is expressed in BAC mice. The literature only mentions that Pitx2 mRNA is expressed in posterior hypothalamus. Additional expression sites include septum and and substantia innominata. The substantia nigra is stained in the postnatal BAC data. However, it is not clear from the DAB staining materials that any cells are labeled inside. The postnatal in situ data from BGEM is not informative.

Other image sets for Pitx2

age	orientation	Acquisition technique	Founder Line	Batch
adult	Horizontal	brightfield	JS66	3 images
adult	Horizontal	confocal	JS66	1 images
adult	Sagittal	brightfield	JS66	10 images
adult	Sagittal	confocal	JS66	2 images
P7	Horizontal	brightfield	JS66	3 images
P7	Sagittal	brightfield	JS66	11 images
P7	Sagittal	confocal	JS66	7 images
E15.5	Horizontal	brightfield	JS66	3 images
E15.5	Sagittal	brightfield	JS66	10 images

BGEM Probe	Related ISH images
Pitx2	3601

Supporting literature:

PubMed ID
11032870
14975719
12453462
12498783
15618518

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Veracity	definition
Confirmed	Confirmed refers to genes in which multiple lines yield matching datasets that agree with the available literature, or in which a single line has been produced that matches the available literature. In those cases where there a discrepancy between the literature and the reporter gene data (missing or additional sites of expression), this is noted in the database.
To Be Confirmed	To be confirmed refers to genes in which multiple lines produce matching datasets, but for which no independent expression data is available.
Anomalous	Anomalous refers to data collected from BAC reporter constructs producing different expression patterns in different lines (i.e. position effects).

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