Section Gene Symbol Age Orientation Objective Veracity Veracity Support 08 aldehyde dehydrogenase family 7, member A1 Aldh7a1 adult Sagittal 10X Confirmed Multiple Lines Match Matches In Situ Data

BX BAC Address marker BX1797 RP23-403H4 EGFP

Other cross-sections of this brain: 01 02 03 04 05 06 07 08 09 10 (thumbnails not to scale)

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Add this image to your album Download this image at the scale shown below. Founder Line: JA59 See all MMRRC strains for : Aldh7a1 Get this mouse from MMRRC: STOCK Tg(Aldh7a1-EGFP)JA59Gsat/Mmucd: Details, Order Get this BAC Clone from CHORI: BX1797 UCSC Genome Browser for this BAC Address: RP23-403H4

Read gene expression annotations for this image View other image sets for Aldh7a1

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Comment on this Gene: No CNS expression literature found. The mutation of the gene is associated with pyridoxine-dependent epilepsy in a considerable number of patients. Two BAC lines have identical expression at P7. By EGFP epifluorescence, it is evident that the BAC is expressed in thalamus, which is not very clear in the P7 DAB staining materials. At adult, BGEM in situ data detects expression of Aldh7a1 mRNA near the Purkinje cells layer. The in situ data from Allen database indicates these Aldh7a1 expressing cells are actually Bergmann glial cells. The BAC data is in agreement with this finding. At E15-5, the BAC is expressed in VZs, but not as strongly as the in situ data indicates. Postmitotic cells in the developing cortex are also stained due to the stability of EGFP protein.

Gene Expression Annotations for this image

structure	Expression Level	Expression Pattern	Cell types	Subtypes
Olfactory Bulb	moderate to strong signal	region-specific and scattered	neuron glial cell
Cerebral cortex	moderate to strong signal	scattered	glial cell
Hippocampus	moderate to strong signal	scattered	glial cell
Caudate Putamen	moderate to strong signal	scattered	glial cell
Ventral striatum	moderate to strong signal	scattered	glial cell
Basal Forebrain	moderate to strong signal	scattered	glial cell
Thalamus	moderate to strong signal	scattered	glial cell
Hypothalamus	moderate to strong signal	scattered	glial cell
Midbrain	moderate to strong signal	scattered	glial cell
Pons	moderate to strong signal	scattered	glial cell
Medulla	moderate to strong signal	scattered	glial cell
Cerebellum	moderate to strong signal	region-specific and scattered	glial cell	Bergmann glia

Other image sets for Aldh7a1

age	orientation	Acquisition technique	Founder Line	Batch
adult	Horizontal	brightfield	JA59	3 images
adult	Sagittal	brightfield	JA59	10 images
adult	Sagittal	confocal	JA59	1 images
P7	Horizontal	brightfield	JA59	3 images
P7	Horizontal	confocal	JA59	1 images
P7	Sagittal	brightfield	JA59	11 images
P7	Sagittal	confocal	JA59	6 images
P7	Sagittal	confocal	JA59	4 images
E15.5	Horizontal	brightfield	JA59	3 images
E15.5	Horizontal	confocal	JA59	1 images
E15.5	Sagittal	brightfield	JA59	10 images
E15.5	Sagittal	confocal	JA59	3 images

BGEM Probe	Related ISH images
Aldh7a1	3049

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Veracity	definition
Confirmed	Confirmed refers to genes in which multiple lines yield matching datasets that agree with the available literature, or in which a single line has been produced that matches the available literature. In those cases where there a discrepancy between the literature and the reporter gene data (missing or additional sites of expression), this is noted in the database.
To Be Confirmed	To be confirmed refers to genes in which multiple lines produce matching datasets, but for which no independent expression data is available.
Anomalous	Anomalous refers to data collected from BAC reporter constructs producing different expression patterns in different lines (i.e. position effects).

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