Section Gene Symbol Age Orientation Objective Veracity Veracity Support 01 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Slc6a4 P7 Sagittal 10X Confirmed Multiple Lines Match Matches In Situ Data Supported by Literature

BX BAC Address marker BX86 RP23-39F11 EGFP

Other cross-sections of this brain: 01 02 03 04 05 06 07 08 09 10 11 (thumbnails not to scale)

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Add this image to your album Download this image at the scale shown below. Founder Line: JP55 See all MMRRC strains for : Slc6a4 Get this mouse from MMRRC: STOCK Tg(Slc6a4-EGFP)JP55Gsat/Mmucd: Details, Order Get this BAC Clone from CHORI: BX86 UCSC Genome Browser for this BAC Address: RP23-39F11

Read gene expression annotations for this image View other image sets for Slc6a4

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Comment on this Gene: According to the literature, serotonin transporter mRNA is primarily localized in raphe nuclei. The BAC data has correct expression in raphe nuclei. Fiber projection are stained across the CNS, giving an impression that EGFP reporter gene is widely expressed inside. In fact, labeled cell bodies are only observed in a few brain areas at P7, including raphe nuclei. Expression is also observed in the MOB, the thalamus and the cortex. These expression sites are transient during the development and are confirmed by Lebrand C et al paper and BGEM in situ data.

Gene Expression Annotations for this image

structure	Expression Level	Expression Pattern	Cell types	Subtypes
Cerebral cortex	moderate to strong signal	region-specific and scattered		fibers
Piriform cortex	moderate to strong signal	scattered		fibers
Entorhinal Cortex	moderate to strong signal	scattered		fibers
Hippocampus	moderate to strong signal	scattered		fibers
Caudate Putamen	moderate to strong signal	scattered		fibers
Amygdala	moderate to strong signal	scattered		fibers
Cerebellum	moderate to strong signal	region-specific and scattered		fibers

Other image sets for Slc6a4

age	orientation	Acquisition technique	Founder Line	Batch
adult	Coronal	brightfield	ET127	16 images
adult	Coronal	brightfield	ET33	24 images
adult	Coronal	brightfield	EZ13	69 images
adult	Coronal	brightfield	EZ8	67 images
adult	Horizontal	brightfield	JP55	3 images
adult	Sagittal	brightfield	JP55	10 images
P7	Horizontal	brightfield	JP55	3 images
P7	Sagittal	brightfield	JP55	11 images
E15.5	Horizontal	brightfield	JP55	3 images
E15.5	Sagittal	brightfield	JP55	10 images

BGEM Probe	Related ISH images
Slc6a4	373

Supporting literature:

PubMed ID
9459551
8121638
9037532
9826275

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Veracity	definition
Confirmed	Confirmed refers to genes in which multiple lines yield matching datasets that agree with the available literature, or in which a single line has been produced that matches the available literature. In those cases where there a discrepancy between the literature and the reporter gene data (missing or additional sites of expression), this is noted in the database.
To Be Confirmed	To be confirmed refers to genes in which multiple lines produce matching datasets, but for which no independent expression data is available.
Anomalous	Anomalous refers to data collected from BAC reporter constructs producing different expression patterns in different lines (i.e. position effects).

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