Section Gene Symbol Age Orientation Objective Veracity Veracity Support 11 thyrotropin releasing hormone receptor Trhr P7 Sagittal 10X Confirmed Matches In Situ Data Supported by Literature

BX BAC Address marker BX1397 RP23-136B22 EGFP

Other cross-sections of this brain: 01 02 03 04 05 06 07 08 09 10 11 (thumbnails not to scale)

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Add this image to your album Download this image at the scale shown below. Founder Line: HU193 See all MMRRC strains for : Trhr Get this mouse from MMRRC: STOCK Tg(Trhr-EGFP)HU193Gsat/Mmucd: Details, Order Get this BAC Clone from CHORI: BX1397 UCSC Genome Browser for this BAC Address: RP23-136B22

Read gene expression annotations for this image View other image sets for Trhr

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Comment on this Gene: The BAC data is consistent with the literature and the in situ data from Allen database and genepaint.org. Confirmed expression sites include motor nuclei in brainstem, motor neurons in spinal cord, AOB (at P7), basal forebrain, amygdala, hypothalamus and substantia nigra. One of the cited papers reports expression of Trhr mRNA in hippocampus and cortex, which is also seen in P7 BAC data and the in situ data from genepaint.org. The BAC detects expression in caudate putamen, mainly confined to the rostral side. The expression is confirmed by the in situ data from genepaint.org. At adult, the BAC shows little expression in accessory olfactory bulb, which is positive in Allen in situ data.

Gene Expression Annotations for this image

structure	Expression Level	Expression Pattern	Cell types	Subtypes
Olfactory Bulb	weak signal	region-specific	glial cell	fibers
Cerebral cortex	weak signal	region-specific	neuron
Septum	weak signal	region-specific	neuron glial cell	fibers
Thalamus	moderate to strong signal	region-specific	neuron
Hypothalamus	moderate to strong signal	region-specific	neuron	fibers
Midbrain	moderate to strong signal	region-specific	neuron	fibers
Pons	moderate to strong signal	region-specific	neuron	fibers
Medulla	moderate to strong signal	region-specific	neuron glial cell	fibers
Cerebellum	moderate to strong signal	region-specific	neuron	interneuron fibers

Other image sets for Trhr

age	orientation	Acquisition technique	Founder Line	Batch
adult	Horizontal	brightfield	HU193	3 images
adult	Sagittal	brightfield	HU193	10 images
P7	Horizontal	brightfield	HU193	3 images
P7	Sagittal	brightfield	HU193	11 images
P7	Sagittal	confocal	HU193	3 images
E15.5	Horizontal	brightfield	HU193	3 images
E15.5	Sagittal	brightfield	HU193	10 images

BGEM Probe	Related ISH images
Trhr	2276

Supporting literature:

PubMed ID
1280790
1488129
8387653
11064370

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Veracity	definition
Confirmed	Confirmed refers to genes in which multiple lines yield matching datasets that agree with the available literature, or in which a single line has been produced that matches the available literature. In those cases where there a discrepancy between the literature and the reporter gene data (missing or additional sites of expression), this is noted in the database.
To Be Confirmed	To be confirmed refers to genes in which multiple lines produce matching datasets, but for which no independent expression data is available.
Anomalous	Anomalous refers to data collected from BAC reporter constructs producing different expression patterns in different lines (i.e. position effects).

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