Section Gene Symbol Age Orientation Objective Veracity Veracity Support 04 aldolase C, fructose-bisphosphate Aldoc P7 Sagittal 10X Confirmed Multiple Lines Match Matches In Situ Data Supported by Literature

BX BAC Address marker BX1126 RP24-353H15 EGFP

Other cross-sections of this brain: 01 02 03 04 05 06 07 08 09 10 11 (thumbnails not to scale)

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Add this image to your album Download this image at the scale shown below. Founder Line: FX220 Get this BAC Clone from CHORI: BX1126 UCSC Genome Browser for this BAC Address: RP24-353H15

Read gene expression annotations for this image View other image sets for Aldoc

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Comment on this Gene: According to the literature, Aldoc is a stripe marker for Purkinje cell compartmental organization inside cerebellum. However, neither the BAC data nor the BGEM data and Allen data detect the stripe pattern of expression within Purkinje cell layer. Multiple BAC lines have identical expression pattern at P7. In BAC mice, the EGFP expression is not restricted to the Purkinje cells in cerebellum. The Bergmann glial cells are also labeled, which is reproducible in multiple BAC lines and confirmed by the in situ data from Allen database. Besides cerebellum, the EGFP transgene is expressed in other brain areas.

Gene Expression Annotations for this image

structure	Expression Level	Expression Pattern	Cell types	Subtypes
Cerebral cortex	moderate to strong signal	widely expressed	glial cell
Hippocampus	moderate to strong signal	region-specific	glial cell
Caudate Putamen	moderate to strong signal	widely expressed	glial cell
Amygdala	moderate to strong signal	widely expressed	glial cell
Pons	moderate to strong signal	widely expressed	glial cell
Cerebellum	moderate to strong signal	region-specific and scattered	glial cell	Bergmann glia

Other image sets for Aldoc

age	orientation	Acquisition technique	Founder Line	Batch
adult	Horizontal	brightfield	FX220	3 images
adult	Sagittal	brightfield	FX220	10 images
adult	Sagittal	confocal	FX220	3 images
P7	Horizontal	brightfield	FX220	3 images
P7	Horizontal	confocal	FX220	1 images
P7	Sagittal	brightfield	FX220	11 images
P7	Sagittal	confocal	FX220	4 images
P7	Sagittal	confocal	FX220	2 images
P7	Sagittal	confocal	FX220	1 images
E15.5	Horizontal	brightfield	FX220	3 images
E15.5	Horizontal	confocal	FX220	2 images
E15.5	Sagittal	brightfield	FX220	10 images
E15.5	Sagittal	confocal	FX220	3 images

BGEM Probe	Related ISH images
Aldoc	159

Supporting literature:

PubMed ID
1430312
10440712
15686102

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Veracity	definition
Confirmed	Confirmed refers to genes in which multiple lines yield matching datasets that agree with the available literature, or in which a single line has been produced that matches the available literature. In those cases where there a discrepancy between the literature and the reporter gene data (missing or additional sites of expression), this is noted in the database.
To Be Confirmed	To be confirmed refers to genes in which multiple lines produce matching datasets, but for which no independent expression data is available.
Anomalous	Anomalous refers to data collected from BAC reporter constructs producing different expression patterns in different lines (i.e. position effects).

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