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Cre mice grouped by gene. (63 Cre lines of which 61 have images.)

In collaboration with the Intramural Program of the National Institute of Mental Health (PI: Dr. Charles Gerfen), GENSAT offers fully characterized transgenic BAC-Cre recombinase driver lines that allow for cell-specific gene manipulations in the central nervous system of the mouse. The aim of this project is to provide the scientific community with Cre driver lines that will target selected neuronal or glial populations in the brain and spinal cord (also see PMID: 17855595).

Click on a thumbnail to see all images for a particular gene and founder line. Or visit the Cre Pipeline to see what else is in production.

Gene Symbol	Gene	Founder Line	Marker	Cre recombination pattern	View	Order from MMRRC
Adora2a	adenosine A2a receptor	KG139	Cre	STRIATUM: indirect pathway (striatopallidal, Drd2) specific		STOCK Tg(Adora2a-cre)KG139Gsat: Details, Order
Cdhr1	cadherin-related family member 1	KG66	Cre	OLFACTORY BULB: mitral cells with projections to piriform cortex		STOCK Tg(Pcdh21-cre)KG66Gsat: Details, Order
Chat	choline acetyltransferase	GM24	Cre	CHOLINERGIC NEURONS: basal forebrain, cortex, striatum, motor neurons in midbrain, brainstem and spinal cord NOTE: lines GM24 and GM60 have identical expression.		STOCK Tg(Chat-cre)GM24Gsat: Details, Order
Chat	choline acetyltransferase	GM60	Cre	CHOLINERGIC NEURONS: basal forebrain, cortex, striatum, motor neurons in midbrain, brainstem and spinal cord NOTE: lines GM24 and GM60 have identical expression		STOCK Tg(Chat-cre)GM60Gsat: Details, Order
Chat	choline acetyltransferase	GM53	Cre	CHOLINERGIC NEURONS: limited to motor neurons in mid brain, brain stem and spinal cord NOTE: minimal forebrain expression		STOCK Tg(Chat-cre)GM53Gsat: Details, Order
Cnnm2	cyclin M2	KD18	Cre	HABENULA: medial habenula CEREBRAL CORTEX: layer 2-6 THALAMUS: scattered BRAIN STEM: select nuclei		STOCK Tg(Cnnm2-cre)KD18Gsat: Register Interest
Cort	cortistatin	IM42	Cre	SUBTHALAMIC NUCLEUS VENTRAL MIDBRAIN: VTA, mammillary nucleus BRAINSTEM: scattered nuclei		STOCK Tg(Cort-cre)IM42Gsat: Details, Order
Crh	corticotropin releasing hormone	KN282	Cre	THALAMUS: ventral nuclei OLFACTORY SYSTEM: anterior olfactory nucleus,nucleus of lateral olfactory tract HYPOTHALAMUS: mammillary and supramammillary nuclei		STOCK Tg(Crh-cre)KN282Gsat: Details, Order
Cxcl11	chemokine (C-X-C motif) ligand 11	KN257	Cre	CEREBELLUM: granule cells CEREBRAL CORTEX: restricted to piriform/amygdala area		NA
Dbh	dopamine beta hydroxylase	KH212	Cre	NORADRENERGIC NEURONS: locus coeruleus (sections p074,075), other noradrenergic brainstem nuclei		STOCK Tg(Dbh-cre)KH212Gsat: Details, Order
Drd1a	dopamine receptor D1A	FK150	Cre	matches adult gene expression pattern, nearly identical to Drd1a line EY262		STOCK Tg(Drd1a-cre)FK150Gsat: Details, Order
Drd1a	dopamine receptor D1A	EY262	Cre	Drd1a NEURONS: matches endogenous expression throughout the brain STRIATUM: direct pathway / striatonigral neurons CEREBRAL CORTEX:layers 5-6 HYPOTHALMUS: select nuclei MIDBRAIN: select nuclei BRAINSTEM: select nuclei		STOCK Tg(Drd1a-cre)EY262Gsat: Details, Order
Drd1a	dopamine receptor D1A	FK164	Cre	NOTE: subset of Drd1a expressing neurons Cerebral cortex: restricted to layer 6b midbrain: pretectal nuclei		STOCK Tg(Drd1a-cre)FK164Gsat: Details, Order
Drd1a	dopamine receptor D1A	EY266	Cre	NOTE: subset of Drd1a expression Accumbens: somewhat restricted to shell Striatum: scattered only subset of striatonigral neurons Amygdala: intercalated nucleus		STOCK Tg(Drd1a-cre)EY266Gsat: Details, Order
Drd1a	dopamine receptor D1A	EY217	Cre	Striatum: striato-nigral specific (Direct pathway) somewhat restricted to dorsal striatum, minimal cortical and other labeling		STOCK Tg(Drd1a-cre)EY217Gsat: Details, Order
Drd1a	dopamine receptor D1A	EY242	Cre	hypothalamus: limited primarily to suprachiasmatic hypothalamic nucleus striatum: scattered dorsal neurons NOTE: subset of Drd1a gene expression		STOCK Tg(Drd1a-cre)EY242Gsat: Details, Order
Drd2	dopamine receptor D2	ER43	Cre	in subset of adult Drd2 expressing neurons (primarily striatopallidal neurons)		STOCK Tg(Drd2-cre)ER43Gsat: Details, Order
Drd2	dopamine receptor D2	ER44	Cre	NOTE: expression in Drd2 neurons Striatum: (striatopallidal neurons) Cereberal Cortex: restricted expression midbrain: dopamine neurons hypothalamus: selected nuclei		STOCK Tg(Drd2-cre)ER44Gsat: Details, Order
Drd3	dopamine receptor D3	KI198	Cre	Hippocampus: most of rostral CA1 most of Dentate Gyrus less in CA2,3		STOCK Tg(Drd3-cre)KI198Gsat: Register Interest
Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	KC112	Cre	extensive expression in hypothalamus, dorsal midbrain (including superior colliculus), hindbrain and brainstem, also olfactory bulb and very restricted in lateral striatum		NA
Gal	galanin	KI87	Cre	hypothalamus: restricted to specific anterior and posterior nuclei retinal ganglion cells brainstem: locus coeruleus		STOCK Tg(Gal-cre)KI87Gsat: Details, Order
Gng7	guanine nucleotide binding protein (G protein), gamma 7	KH71	Cre	Striatum: both direct (Drd1a) and indirect (Drd2) output pathways cerebral cortex: scattered in layer 5 hippocampus: scattered CA1 and dentate granule cells		STOCK Tg(Gng7-cre)KH71Gsat: Details, Order
Gng7	guanine nucleotide binding protein (G protein), gamma 7	KH67	Cre	Striatum: both direct (Drd1a) and indirect (Drd2) output pathways cerebral cortex: scattered in layer 5 hippocampus: scattered CA1 and dentate granule cells		STOCK Tg(Gng7-cre)KH67Gsat: Details, Order
Gpr26	G protein-coupled receptor 26	KO273	Cre	cerebral cortex: primary somatosensory cortex, layer 3,scattered layer 5		STOCK Tg(Gpr26-cre)KO273Gsat: Register Interest
Gpr26	G protein-coupled receptor 26	KO250	Cre	cerebral cortex: layer 5 motor areas hippocampus: rostral CA1 thalamus: posterior (motor) related nuclei Cerebellum: select areas		STOCK Tg(Gpr26-cre)KO250Gsat: Register Interest
Grm2	glutamate receptor, metabotropic 2	MR90-CRE	Cre	Cerebral cortex: frontal, motor, cingluate, piriform areas hippocampus: dentate granule cells thalamus: select nuclei including intralaminar amygdala: medial nuclei midbrain: central grey and mammillary nuclei		NA
Grp	gastrin releasing peptide	KH288	Cre	expression in specific frontal cortical areas and thalamus		STOCK Tg(Grp-cre)KH288Gsat: Details, Order
Grp	gastrin releasing peptide	KH107	Cre	NA	no images available	STOCK Tg(Grp-cre)KH107Gsat: Details, Order
Hdc	histidine decarboxylase	IM1	Cre	hypothalamus: tuberomammillary nucleus (TMN, coronal levels P53,54,55,56) NOTE: TMN is the source of histamine projections to the forebrain		STOCK Tg(Hdc-cre)IM1Gsat: Details, Order
Hdc	histidine decarboxylase	IM4	Cre	NOTE: identical to IM1 hypothalamus: tuberomammillary nucleus (TMN) TMN is the source of histamine projections to the forebrain,	no images available	STOCK Tg(Hdc-cre)IM4Gsat: Register Interest
Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	KM207	Cre	Septal area: Lateral septal nuclei Cerebral cortex: frontal cortical areas, partial layer 5 and 6b Thalamus: moderate labeling of select nuclei Amygdala: medial nuclei Hypothalamus: scattered nuclei Brainstem: select nuclei		STOCK Tg(Htr2a-cre)KM207Gsat: Details, Order
Kera	keratocan	IM23	Cre	hippocampus: caudal CA1 primarily		STOCK Tg(Kera-cre)23Gsat: Details, Order
Mpp3	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	KG118	Cre	hippocampus: most of CA2,3,4 little in CA1 brainstem: inferior olive		STOCK Tg(Mpp3-cre)KG118Gsat: Register Interest
Ntsr1	neurotensin receptor 1	GN220	Cre	neocortex layer 6		B6.Cg-Tg(Ntsr1-cre)GN220Gsat/Mmcd: Details, Order
Ntsr1	neurotensin receptor 1	GN209	Cre	expression in piriform cortex, inferior colliculus and stripes in the cerebellum		STOCK Tg(Ntsr1-cre)209Gsat: Details, Order
Pcp2	Purkinje cell protein 2 (L7)	GN137	Cre	Cerebellum: Purkinje cells NOTE: matches endogenous gene expression		STOCK Tg(Pcp2-cre)GN137Gsat: Details, Order
Pcp2	Purkinje cell protein 2 (L7)	GN135	Cre	Cerebellum: Purkinje cells NOTE: matches endogenous gene expression, identical to GN137		STOCK Tg(Pcp2-cre)GN135Gsat: Details, Order
Pde1c	phosphodiesterase 1C	IT146	Cre	Cerebral cortex: piriform and olfactory related areas Brainstem: pontine reticular complex, other select nuclei Cerebellum: widespread labeling		STOCK Tg(Pde1c-cre)IT146Gsat: Details, Order
Pde1c	phosphodiesterase 1C	IT106	Cre	Brainstem: pontine reticular complex, other select nuclei Cerebellum: widespread labeling		STOCK Tg(Pde1c-cre)IT106Gsat: Details, Order
Pdzk1ip1	PDZK1 interacting protein 1	KD31	Cre	midbrain: extensive labeling in the dorsal and ventral midbrain in select nuclei, including superior colliculus, substantia nigra and central grey nuclei		STOCK Tg(Pdzk1ip1-cre)KD31Gsat: Details, Order
Pdzk1ip1	PDZK1 interacting protein 1	KD27	Cre	midbrain: extensive labeling in the dorsal and ventral midbrain in select nuclei, including superior colliculus, substantia nigra and central grey nuclei		NA
Pmch	pro-melanin-concentrating hormone	KY133	Cre	Hypothalamus: restricted to nuclei producing Pmch		NA
Rbp4	retinol binding protein 4, plasma	KL100	Cre	Cerebral Cortex: layer 5 pyramidal tract neurons (and corticostriatal) piriform cortex hippocampus		STOCK Tg(Rbp4-cre)KL100Gsat: Register Interest
Satb2	special AT-rich sequence binding protein 2	MO23-CRE	Cre	Cerebral Cortex: Layer 5 and 6 of neocortex		NA
Sim1	single-minded homolog 1 (Drosophila)	KJ18	Cre	hypothalamus: widespread in multiple nuclei including PVN cortex: widespread scattered layer 5 amygdala: medial nuclei		STOCK Tg(Sim1-cre)KJ18Gsat: Details, Order
Sim1	single-minded homolog 1 (Drosophila)	KJ40	Cre	hypothalamus: multiple nuclei, including PVN Amygdala: medial nuclei, Nucleus Lateral Olfactory Tract Mammillary bodies: nuclei giving rise to mammillothalamic tract		NA
Sim1	single-minded homolog 1 (Drosophila)	KJ27	Cre	hypothalamus: widespread in multiple nuclei including PVN cortex: widespread scattered layer 3-5 amygdala: medial nuclei		STOCK Tg(Sim1-cre)KJ27Gsat: Details, Order
Sim1	single-minded homolog 1 (Drosophila)	KJ21	Cre	hypothalamus: multiple nuclei, including PVN Amygdala: medial nuclei, Nucleus Lateral Olfactory Tract hippocampus: dorsal CA1 cerebral cortex: restricted part of entorhinal cortex		NA
Sla	src-like adaptor	KJ319	Cre	Cereberal cortex: partial labeling of pyramidal neurons in layers 2-6 of neocortex Cerebellum: granule cells		NA
Sla	src-like adaptor	KJ303	Cre	cerebral cortex: supraganular layers of much of neocortex nucleus of the lateral olfactory tract		NA
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	EZ8	Cre-ER (inducible)	Inducible Cre expression in serotonin neurons. Tamoxifen (6-10 mg/kg, ip) injected 1-3 times in the adult induces Cre restricted to serotonin neurons (no apparent labeling in cortex)		STOCK Tg(Slc6a4-cre/ERT2)EZ8Gsat: Details, Order
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	ET33	Cre	matches adult gene expression (serotonin neurons and sparse numbers in cortex)		STOCK Tg(Slc6a4-cre)ET33Gsat: Details, Order
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	ET127	Cre	matches adult (serotonin neurons) and developmental (neocortex layer 6) gene expression		STOCK Tg(Slc6a4-cre)ET127Gsat: Details, Order
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	EZ13	Cre-ER (inducible)	Inducible Cre expression in serotonin neurons. Tamoxifen (6-10 mg/kg, ip) injected 1-3 times in the adult induces Cre restricted to serotonin neurons (no apparent labeling in cortex)		STOCK Tg(Slc6a4-cre/ERT2)EZ13Gsat: Details, Order
Slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	KF109	Cre	very specific expression in glycinergic neurons in brainstem		STOCK Tg(Slc6a5-cre)KF109Gsat: Details, Order
Syt17	synaptotagmin XVII	NO14-CRE	Cre	midbrain: specific labeling of VTA dopamine neurons ( possible labeling of non-DA VTA neurons as well)		NA
Syt6	synaptotagmin VI	KI148	Cre	Cerebral cortex: frontal,congulate and motor related areas, layer 6 thalamocortical neurons Striatum: enriched in patches thalamus: medial habenula neurons, terminals from cortex midbrain: scattered neurons, including SNr cerebellum: widespread varied labeling		STOCK Tg(Syt6-cre)KI148Gsat: Details, Order
Th	tyrosine hydroxylase	FI12	Cre	matches adult and developmental gene expression		STOCK Tg(Th-cre)FI12Gsat: Details, Order
Th	tyrosine hydroxylase	FI172	Cre	matches adult and developmental gene expression, identical to line FI12		STOCK Tg(Th-cre)FI172Gsat: Details, Order
Ucn3	urocortin 3	KF43	Cre	Cre restricted to hypothalamus (principally lateral hypothalamus), some in medial amygdala		STOCK Tg(Ucn3-cre)KF43Gsat: Details, Order
Ucn3	urocortin 3	KF31	Cre	expression in specific hypothalamic nuclei		STOCK Tg(Ucn3-cre)KF31Gsat: Register Interest
Vipr2	vasoactive intestinal peptide receptor 2	KH234	Cre	expression in specific layers of cerebral cortex, in specific thalamic nuclei, and midbrain (superior colliculus and LGN)		NA
Wnt5a	wingless-related MMTV integration site 5A	ML10-CRE	Cre			NA

38 total genes of which 38 genes have images.
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